The Foundation works at the national as well as international levels through franchises and offices. Few examples are Epilepsy Foundation of New Jersey, Epilepsy Foundation of Michigan, and Epilepsy Foundation of Colorado. The primary aim is to ensure that patients take part in all activities performed by healthy person. The agency also undertakes research on possible preventive and curative methods for the disorder. It also takes effort to change legislative laws toward enabling epileptics have equal opportunities as other citizens.

The agency conducts various programs that aid in research, improve women's health, and encourage the public to help epileptics. Popular programs are Epilepsy Gene Discovery Project and H.O.P.E. (Helping Other People with Epilepsy) Mentoring Program.

Services provided by the Foundation include, counseling, awareness programs, conducting camps for children and teenagers, holding meetings to educate large communities and creating support groups to get closer to people.

The Foundation gets a majority of its funds from philanthropists and lesser amounts from government and private sources.

Top-notch professionals, businessmen, and other elite members of the society form the Board of Directors. The Foundation also has a Professional Advisory Board that comprises experts in epilepsy.

Apart from the US, the Foundation also works in other continents such as Australia through the Epilepsy Foundation of Victoria.